Compounds > (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone

(4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone and Parkinson-Disease

(4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone has been researched along with Parkinson-Disease* in 1 studies

Other Studies

1 other study(ies) available for (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone and Parkinson-Disease

Article	Year
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.), 2007, Jul-27, Volume: 317, Issue:5837 The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging. Topics: Acetylation; alpha-Synuclein; Animals; Animals, Genetically Modified; Cell Death; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drosophila melanogaster; Furans; Humans; Models, Molecular; Neurons; Parkinson Disease; Protein Conformation; Quinolines; Rats; RNA, Small Interfering; Sirtuin 1; Sirtuin 2; Sirtuins; Transfection; Tubulin	2007

Article

Year

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

Science (New York, N.Y.), 2007, Jul-27, Volume: 317, Issue:5837

The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.

Topics: Acetylation; alpha-Synuclein; Animals; Animals, Genetically Modified; Cell Death; Cell Line, Tumor; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drosophila melanogaster; Furans; Humans; Models, Molecular; Neurons; Parkinson Disease; Protein Conformation; Quinolines; Rats; RNA, Small Interfering; Sirtuin 1; Sirtuin 2; Sirtuins; Transfection; Tubulin

2007